B cell strategy to maintain remission in ANCA-associated vasculitides?
نویسندگان
چکیده
منابع مشابه
Updates in ANCA-associated vasculitis.
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknow...
متن کاملNew horizons for treatment of ANCA-associated vasculitides.
The field of ANCA-associated vasculitis therapy is currently undergoing probably the most momentous change since the effectiveness of adjunctive CYC to treat granulomatosis with polyangitiis (Wegener’s) was discovered in the early 1970s [1, 2]. Since 2001 [3], the numerous uncontrolled observations reporting the efficacy of the chimeric monoclonal anti-CD20 antibody rituximab against granulomat...
متن کاملUse of methotrexate in ANCA-associated vasculitides.
Since the introduction of combined immunosuppressive therapy consisting of oral cyclophosphamide (CYC) and glucocorticosteroids (GC) in the 1970s, the outcome of antineutrophil cystoplasmic antibodies (ANCA)-associated vasculitides has improved dramatically over the last decades. However, the long-term follow-up of patients treated with CYC plus GC has revealed a high treatment-related morbidit...
متن کاملRituximab versus azathioprine for maintenance in ANCA-associated vasculitis.
BACKGROUND The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitides. However, even when patients receive maintenance treatment with azathioprine or methotrexate, the relapse rate remains high. Rituximab may help to maintain remission. METHODS Patients with newly diagnosed or relapsing gran...
متن کامل[Treatment of anti-neutrophil cytoplasmic antibody related vasculitis].
ANCA-associated vasculitides are a well-known clinico-pathological group of systemic diseases comprising microscopic poliangiitis, granulomatosis with poliangiitis and eosinophilic granulomatosis with poliangiitis. This article shows contemporary treatment of this diseases with extensive literature review. Stepwise treatment of ANCA-associated vasculitides is divided into induction therapy and ...
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عنوان ژورنال:
- The Journal of rheumatology
دوره 39 1 شماره
صفحات -
تاریخ انتشار 2012